Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. Germline and somatically acquired ALK aberrations induce increased autophosphorylation, constitutive ALK activation and increased do...

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Autors principals: Carpenter, EL, Haglund, EA, Mace, EM, Deng, D, Martinez, D, Wood, AC, Chow, AK, Weiser, DA, Belcastro, LT, Winter, C, Bresler, SC, Asgharzadeh, S, Seeger, RC, Zhao, H, Guo, R, Christensen, JG, Orange, JS, Pawel, BR, Lemmon, MA, Mossé, YP
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730824/
https://ncbi.nlm.nih.gov/pubmed/22266870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.647
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