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Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A
Translation is regulated predominantly at the initiation phase by several signal transduction pathways that are often usurped in human cancers, including the PI3K/Akt/mTOR axis. mTOR exerts unique administration over translation by regulating assembly of eukaryotic initiation factor (eIF) 4F, a hete...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3730203/ https://ncbi.nlm.nih.gov/pubmed/23872707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.25 |
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