Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site

The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G. In contrast, low micromolar concentrations of cadmium did not inhibit PP1 or tyrosine pho...

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Autors principals: Pan, Chang, Liu, Hong-Da, Gong, Zheng, Yu, Xiao, Hou, Xu-Ben, Xie, Di-Dong, Zhu, Xi-Bin, Li, Hao-Wen, Tang, Jun-Yi, Xu, Yun-Fei, Yu, Jia-Qi, Zhang, Lian-Ying, Fang, Hao, Xiao, Kun-Hong, Chen, Yu-Guo, Wang, Jiang-Yun, Pang, Qi, Chen, Wei, Sun, Jin-Peng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730172/
https://ncbi.nlm.nih.gov/pubmed/23903585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02333
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