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Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G. In contrast, low micromolar concentrations of cadmium did not inhibit PP1 or tyrosine pho...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3730172/ https://ncbi.nlm.nih.gov/pubmed/23903585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02333 |
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