Noninvasive Monitoring of Pharmacodynamics and Kinetics of a Death Receptor 5 Antibody and Its Enhanced Apoptosis Induction in Sequential Application with Doxorubicin

Induction of apoptosis plays a crucial role in the response of tumors to treatment. Thus, we investigated the pharmacodynamics and tumor saturation kinetics of a death receptor 5 antibody (anti-DR5) when combined with chemotherapeutics. For our investigations, we applied an imaging method that allow...

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Bibliographic Details
Main Authors: Weber, Thomas G, Pöschinger, Thomas, Galbán, Stefanie, Rehemtulla, Alnawaz, Scheuer, Werner
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730039/
https://ncbi.nlm.nih.gov/pubmed/23908588
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