HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma

Heat shock protein 90 (HSP90) is a chaperone protein that stabilizes proteins involved in oncogenic and therapeutic resistance pathways of epithelial cancers, including head and neck squamous cell carcinomas (HNSCCs). Here, we characterized the molecular, cellular, and preclinical activity of HSP90...

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Main Authors: Friedman, Jay A, Wise, Stephanie C, Hu, Michael, Gouveia, Chris, Vander Broek, Robert, Freudlsperger, Christian, Kannabiran, Vishnu R, Arun, Pattatheyil, Mitchell, James B, Chen, Zhong, Van Waes, Carter
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730018/
https://ncbi.nlm.nih.gov/pubmed/23908686
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