Effect of oral sodium bicarbonate supplementation on progression of chronic kidney disease in patients with chronic metabolic acidosis: study protocol for a randomized controlled trial (SoBic-Study)

BACKGROUND: Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m(2). The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutral...

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Autors principals: Gaggl, Martina, Cejka, Daniel, Plischke, Max, Heinze, Georg, Fraunschiel, Melanie, Schmidt, Alice, Hörl, Walter H, Sunder-Plassmann, Gere
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Study Protocol
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729547/
https://ncbi.nlm.nih.gov/pubmed/23826760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-14-196
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