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Differential binding of pyruvate dehydrogenase complex-E2 (PDC-E2) epitopes by DRB1*08:01 and DRB1*11:01 is predicted by their structural motifs and correlates with disease risk(,)
DRB1*08:01 (DR0801) and DRB1*11:01 (DR1101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary cirrhosis (PBC). DR0801 confers risk and shares a key feature with other HLA class II alleles that predispose to autoimmunity: a non-aspartic acid at beta57. DR11...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729472/ https://ncbi.nlm.nih.gov/pubmed/23543758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202445 |
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