Differential binding of pyruvate dehydrogenase complex-E2 (PDC-E2) epitopes by DRB1*08:01 and DRB1*11:01 is predicted by their structural motifs and correlates with disease risk(,)

DRB1*08:01 (DR0801) and DRB1*11:01 (DR1101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary cirrhosis (PBC). DR0801 confers risk and shares a key feature with other HLA class II alleles that predispose to autoimmunity: a non-aspartic acid at beta57. DR11...

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Main Authors: Chow, I-Ting, James, Eddie A., Gates, Theresa J., Tan, Venus, Moustakas, Antonis K., Papadopoulos, George K., Kwok, William W.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729472/
https://ncbi.nlm.nih.gov/pubmed/23543758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202445
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