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Deletion of Cx43 from osteocytes results in defective bone material properties but does not decrease extrinsic strength in cortical bone

Deletion of connexin (Cx) 43 from osteoblasts and osteocytes (OCN-Cre;Cx43(fl/−) mice) or from osteocytes only (DMP1-8kb-Cre;Cx43(fl/fl) mice) results in increased cortical, but not cancellous, osteocyte apoptosis and widening of the femoral midshaft without changes in cortical thickness. Despite th...

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Autors principals: Bivi, Nicoletta, Nelson, Mark T., Faillace, Meghan E., Li, Jiliang, Miller, Lisa M., Plotkin, Lilian I.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729333/
https://ncbi.nlm.nih.gov/pubmed/22865265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-012-9628-z
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