N-4-t-Butylbenzyl 2-(4-Methylsulfonylaminophenyl) Propanamide TRPV1 Antagonists : Structure Activity Relationships in the A-region

Structure activity relationships for the A-region in a series of N-4-t-butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamides as TRPV1 antagonists have been investigated. Among them, the 3-fluoro analogue 54 showed high binding affinity and potent antagonism for both rTRPV1 and hTRPV1 in CHO cells...

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Bibliografiske detaljer
Main Authors: Kim, Yongsoo, Kil, Min-Jung, Kang, Sang-Uk, Choi, Hyun-Kyung, Ryu, HyungChul, Choi, Yeon-Sil, Cho, Sook-Hyun, Cho, Yongsung, Bhondwe, Rahul S., Lee, Jin Hee, Choi, Sun, Pearce, Larry V., Pavlyukovets, Vladimir A., Morgan, Matthew A., Tran, Richard, Lazar, Jozsef, Blumberg, Peter M., Lee, Jeewoo
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729215/
https://ncbi.nlm.nih.gov/pubmed/22169633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.11.008
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