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Reconstruction of Cellular Signal Transduction Networks Using Perturbation Assays and Linear Programming

Perturbation experiments for example using RNA interference (RNAi) offer an attractive way to elucidate gene function in a high throughput fashion. The placement of hit genes in their functional context and the inference of underlying networks from such data, however, are challenging tasks. One of t...

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Detalhes bibliográficos
Main Authors: Knapp, Bettina, Kaderali, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728289/
https://ncbi.nlm.nih.gov/pubmed/23935958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069220
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