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Enhance the binding affinity of fluorophore-aptamer pairs for RNA tagging with neomycin conjugation
Fluorogenic sulforhodamine-neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250–400 fold enhancement in binding affinity relative to corresponding unconjugtaed fluorophores.
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728288/ https://ncbi.nlm.nih.gov/pubmed/22951899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc34498j |
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