Design and application of a novel PNA probe for the detection at single cell level of JAK2(V617F) mutation in Myeloproliferative Neoplasms

BACKGROUND: Mutation(s) of the JAK2 gene (V617F) has been described in a significant proportion of Philadelphia negative Myeloproliferative Neoplasms (MPN) patients and its detection is now a cornerstone in the diagnostic algorithm. METHODS: We developed a novel assay based on peptide nucleic acid (...

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Hauptverfasser: Bracco, Enrico, Rosso, Valentina, Serra, Anna, Carnuccio, Francesca, Gaidano, Valentina, Nicoli, Paolo, Musto, Pellegrino, Saglio, Giuseppe, Frassoni, Francesco, Cilloni, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728119/
https://ncbi.nlm.nih.gov/pubmed/23865766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-348
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