Specific inhibition of one DNMT1-including complex influences tumor initiation and progression

BACKGROUND: Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhance tumorigenesis via DNA hypomethylation-induced oncogene activation and chromosomal instability. To...

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Autores principales: Cheray, Mathilde, Pacaud, Romain, Nadaradjane, Arulraj, Vallette, François M, Cartron, Pierre-François
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727981/
https://ncbi.nlm.nih.gov/pubmed/23809695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-5-9
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