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Specific inhibition of one DNMT1-including complex influences tumor initiation and progression
BACKGROUND: Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhance tumorigenesis via DNA hypomethylation-induced oncogene activation and chromosomal instability. To...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3727981/ https://ncbi.nlm.nih.gov/pubmed/23809695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-5-9 |
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