Specific inhibition of one DNMT1-including complex influences tumor initiation and progression

BACKGROUND: Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhance tumorigenesis via DNA hypomethylation-induced oncogene activation and chromosomal instability. To...

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Bibliographic Details
Main Authors: Cheray, Mathilde, Pacaud, Romain, Nadaradjane, Arulraj, Vallette, François M, Cartron, Pierre-François
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727981/
https://ncbi.nlm.nih.gov/pubmed/23809695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-5-9
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