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Selective constraint, background selection, and mutation accumulation variability within and between human populations

BACKGROUND: Regions of the genome that are under evolutionary constraint across multiple species have previously been used to identify functional sequences in the human genome. Furthermore, it is known that there is an inverse relationship between evolutionary constraint and the allele frequency of...

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Detalhes bibliográficos
Main Authors: Hodgkinson, Alan, Casals, Ferran, Idaghdour, Youssef, Grenier, Jean-Christophe, Hernandez, Ryan D, Awadalla, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727949/
https://ncbi.nlm.nih.gov/pubmed/23875710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-495
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