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Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules
The neonatal receptor for immunoglobulin G (IgG; FcRn) prevents IgG degradation by efficiently sorting IgG into recycling endosomes and away from lysosomes. When bound to IgG-opsonized antigen complexes, however, FcRn traffics cargo into lysosomes, where antigen processing can occur. Here we address...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3727932/ https://ncbi.nlm.nih.gov/pubmed/23741050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0174 |
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