Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules

The neonatal receptor for immunoglobulin G (IgG; FcRn) prevents IgG degradation by efficiently sorting IgG into recycling endosomes and away from lysosomes. When bound to IgG-opsonized antigen complexes, however, FcRn traffics cargo into lysosomes, where antigen processing can occur. Here we address...

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Bibliografiske detaljer
Main Authors: Weflen, Andrew W., Baier, Nina, Tang, Qing-Juan, Van den Hof, Malon, Blumberg, Richard S., Lencer, Wayne I., Massol, Ramiro H.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727932/
https://ncbi.nlm.nih.gov/pubmed/23741050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0174
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