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Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis()

IL-17- and IFN-γ-secreting T cells play an important role in autoimmune responses in multiple sclerosis and the model system experimental autoimmune encephalomyelitis (EAE). Dendritic cells (DCs) in the periphery and microglia in the CNS are responsible for cytokine polarization and expansion of thi...

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Bibliografiske detaljer
Main Authors: Skarica, Mario, Wang, Tianhong, McCadden, Erin, Kardian, David, Calabresi, Peter A., Small, Donald, Whartenby, Katharine A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727416/
https://ncbi.nlm.nih.gov/pubmed/19299717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803631
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