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TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA

Type I interferon (IFN) is an important host defense cytokine against intracellular pathogens, mainly viruses. In assessing IFN production in response to group B streptococcus (GBS), we find that IFN-β was produced by macrophages upon stimulation with both heat-killed and live GBS. Exposure of macro...

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Bibliografiske detaljer
Main Authors: Charrel-Dennis, Marie, Latz, Eicke, Halmen, Kristen A., Trieu-Cuot, Patrick, Fitzgerald, Katherine A., Kasper, Dennis L., Golenbock, Douglas T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727391/
https://ncbi.nlm.nih.gov/pubmed/19064255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.11.002
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