Deep Sequencing Analysis of HCV NS3 Resistance-Associated Variants and Mutation Linkage in Liver Transplant Recipients

Viral variants with decreased susceptibility to HCV protease inhibitors (PIs) occur naturally and preexist at low levels within HCV populations. In patients failing PI monotherapy, single and double mutants conferring intermediate to high-level resistance to PIs have been selected in vivo. The abund...

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Main Authors: Kirst, Mariana E., Li, Eric C., Wang, Cindy X., Dong, Hui-Jia, Liu, Chen, Fried, Michael W., Nelson, David R., Wang, Gary P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726766/
https://ncbi.nlm.nih.gov/pubmed/23922778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069698
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