Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase

BACKGROUND: Angiogenesis is tightly linked to inflammation and cancer. Regulation of angiogenesis is mediated primarily through activation of receptor tyrosine kinases, thus kinase inhibitors represent a new paradigm in anti-cancer therapy. However, these inhibitors have broad effects on inflammator...

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Autors principals: Sanchez, Alma, Tripathy, Debjani, Yin, Xiangling, Luo, Jinhua, Martinez, Joseph M, Grammas, Paula
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726353/
https://ncbi.nlm.nih.gov/pubmed/23880112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-93
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