Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

Considerable evidence implicates hypoxia and vascular inflammation in Alzheimer's disease (AD). Thrombin, a multifunctional inflammatory mediator, is demonstrable in the brains of AD patients both in the vessel walls and senile plaques. Hypoxia-inducible factor 1α (HIF-1α), a key regulator of t...

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Detalles Bibliográficos
Autores principales: Tripathy, Debjani, Sanchez, Alma, Yin, Xiangling, Luo, Jinhua, Martinez, Joseph, Grammas, Paula
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648692/
https://ncbi.nlm.nih.gov/pubmed/23675346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2013.00019
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