Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation

Genotoxic stress activation of the tumor suppressor transcription factor p53 involves post-translational C-terminal modifications that increase both protein stability and DNA binding activity. We compared the requirement for p53 protein activation of p53 target sequences in two major p53-regulated g...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Kaku, Shinsuke, Iwahashi, Yuki, Kuraishi, Aiko, Albor, Amador, Yamagishi, Takehiro, Nakaike, Shiro, Kulesz-Martin, Molly
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2001
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11328884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.9.1989
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