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A Small Molecule Inhibitor of Redox-Regulated Protein Translocation into Mitochondria
The mitochondrial disulfide relay system of Mia40 and Erv1/ALR facilitates import of the small Translocase of the Inner Membrane (Tim) proteins and cysteine rich proteins. A chemical screen identified small molecules that inhibit Erv1 oxidase activity, thereby facilitating dissection of the disulfid...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726224/ https://ncbi.nlm.nih.gov/pubmed/23597483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.03.006 |
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