A Small Molecule Inhibitor of Redox-Regulated Protein Translocation into Mitochondria

The mitochondrial disulfide relay system of Mia40 and Erv1/ALR facilitates import of the small Translocase of the Inner Membrane (Tim) proteins and cysteine rich proteins. A chemical screen identified small molecules that inhibit Erv1 oxidase activity, thereby facilitating dissection of the disulfid...

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Main Authors: Dabir, Deepa V., Hasson, Samuel A., Setoguchi, Kiyoko, Johnson, Meghan E., Wongkongkathep, Piriya, Douglas, Colin J., Zimmerman, Johannes, Damoiseaux, Robert, Teitell, Michael A., Koehler, Carla M.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726224/
https://ncbi.nlm.nih.gov/pubmed/23597483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.03.006
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