IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity

Background. Systemic administration of IL-12p70 has demonstrated clinical activity in cancer patients, but dose-limiting toxicities have hindered its incorporation in vaccine formulations. Here, we report on the immunological and clinical outcomes upon vaccination with CD40L/IFN-γ–matured, IL-12p70–...

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Detalhes bibliográficos
Main Authors: Carreno, Beatriz M., Becker-Hapak, Michelle, Huang, Alexander, Chan, Megan, Alyasiry, Amer, Lie, Wen-Rong, Aft, Rebecca L., Cornelius, Lynn A., Trinkaus, Kathryn M., Linette, Gerald P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726168/
https://ncbi.nlm.nih.gov/pubmed/23867552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68395
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