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LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

Liver X receptors (LXR) are stimulated by cholesterol-derived oxysterols and serve as transcription factors to regulate gene expression in response to alterations in cholesterol. In the present study, we investigated the role of LXRs in vascular endothelial cells (ECs) and discovered that LXRβ has n...

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Detalhes bibliográficos
Main Authors: Ishikawa, Tomonori, Yuhanna, Ivan S., Umetani, Junko, Lee, Wan-Ru, Korach, Kenneth S., Shaul, Philip W., Umetani, Michihisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726156/
https://ncbi.nlm.nih.gov/pubmed/23867501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66533
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