Reduced thrombin binding and aggregation in Bernard-Soulier platelets.
Platelets from two patients with Bernard-Soulier disease showed a reduction in their ability to bind human thrombin. Thrombin binding studies in the high affinity range showed 1,500 sites for the Bernard-Soulier platelets as against 4,000 for normal controls. However, the dissociation constant was t...
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| Published in: | J Clin Invest |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1978
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372601/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/641158/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109000 |
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