Chromatin-Modifying Agents Reactivate Embryonic Renal Stem/Progenitor Genes in Human Adult Kidney Epithelial Cells but Abrogate Dedifferentiation and Stemness

Recent studies have suggested that epigenetic modulation with chromatin-modifying agents can induce stemness and dedifferentiation and increase developmental plasticity. For instance, valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has been shown to promote self-renewal/expansion of hem...

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Hlavní autoři: Omer, Dorit, Harari-Steinberg, Orit, Buzhor, Ella, Metsuyanim, Sally, Pleniceanu, Oren, Zundelevich, Adi, Gal-Yam, Einav Nili, Dekel, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2013
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725946/
https://ncbi.nlm.nih.gov/pubmed/23841748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2012.0087
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