Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner

Cell line studies have previously demonstrated that hypoxia-reoxygenation (H/R) leads to the production of NADPH oxidase 1 and 2 (NOX1 and NOX2)-dependent reactive oxygen species (ROS) required for the activation of c-Src and NF-κB. We now extend these studies into mouse models to evaluate the contr...

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Detalhes bibliográficos
Main Authors: Spencer, Netanya Y., Zhou, Weihong, Li, Qiang, Zhang, Yulong, Luo, Meihui, Yan, Ziying, Lynch, Thomas J., Abbott, Duane, Banfi, Botond, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725690/
https://ncbi.nlm.nih.gov/pubmed/23639811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00430.2012
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