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Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these extracellular c...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725624/ https://ncbi.nlm.nih.gov/pubmed/23677799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00074.2013 |
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