Arginase 1 Mediates Increased Blood Pressure and Contributes to Vascular Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertension

Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide production and impairs endothelial function in vascular pathologies. Using a gene deletion model, we investigated involvement of arginase isoforms arginase 1 and 2 (ARG1 and ARG2) in hypertension and endotheli...

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Hlavní autoři: Toque, Haroldo A., Nunes, Kenia P., Rojas, Modesto, Bhatta, Anil, Yao, Lin, Xu, Zhimin, Romero, Maritza J., Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2013
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725429/
https://ncbi.nlm.nih.gov/pubmed/23908657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00219
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