Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer

Approximately 70% of patients with non–small-cell lung cancer present with late-stage disease and have limited treatment options, so there is a pressing need to develop efficacious targeted therapies for these patients. This remains a major challenge as the underlying genetic causes of ∼50% of non–s...

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Autori principali: Fawdar, Shameem, Trotter, Eleanor W., Li, Yaoyong, Stephenson, Natalie L., Hanke, Franziska, Marusiak, Anna A., Edwards, Zoe C., Ientile, Sara, Waszkowycz, Bohdan, Miller, Crispin J., Brognard, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725071/
https://ncbi.nlm.nih.gov/pubmed/23836671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305207110
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