Optimizing Nasal Potential Difference Analysis for CFTR Modulator Development: Assessment of Ivacaftor in CF Subjects with the G551D-CFTR Mutation

Nasal potential difference (NPD) is used as a biomarker of the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) activity. We evaluated methods to detect changes in chloride and sodium transport by NPD based on a secondary analysis of a Phase II CFTR-mod...

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Main Authors: Rowe, Steven M., Liu, Bo, Hill, Aubrey, Hathorne, Heather, Cohen, Morty, Beamer, John R., Accurso, Frank J., Dong, Qunming, Ordoñez, Claudia L., Stone, Anne J., Olson, Eric R., Clancy, John P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724869/
https://ncbi.nlm.nih.gov/pubmed/23922647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066955
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