Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

c-Src kinase activity is regulated by phosphorylation of Y527 and Y416. Y527 phosphorylation stabilizes a closed conformation, which suppresses kinase activity towards substrates, whereas phosphorylation at Y416 promotes an elevated kinase activity by stabilizing the activation loop in a manner perm...

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Hlavní autoři: Irtegun, Sevgi, Wood, Rebecca J., Ormsby, Angelique R., Mulhern, Terrence D., Hatters, Danny M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724807/
https://ncbi.nlm.nih.gov/pubmed/23923048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071035
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