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Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src
c-Src kinase activity is regulated by phosphorylation of Y527 and Y416. Y527 phosphorylation stabilizes a closed conformation, which suppresses kinase activity towards substrates, whereas phosphorylation at Y416 promotes an elevated kinase activity by stabilizing the activation loop in a manner perm...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724807/ https://ncbi.nlm.nih.gov/pubmed/23923048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071035 |
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