Histone Deacetylase Inhibitor Upregulates Peroxisomal Fatty Acid Oxidation and Inhibits Apoptotic Cell Death in Abcd1-Deficient Glial Cells

In X-ALD, mutation/deletion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes. While loss of Abcd1 in astrocytes produces a robust inflammatory response, the oligodendrocytes undergo cell death le...

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Hlavní autoři: Singh, Jaspreet, Khan, Mushfiquddin, Pujol, Aurora, Baarine, Mauhamad, Singh, Inderjit
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724778/
https://ncbi.nlm.nih.gov/pubmed/23923017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070712
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