Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

X-linked adrenoleukodystrophy is a metabolic disorder arising from a mutation/deletion in the ABCD1 gene, leading to a defect in the peroxisomal adrenoleukodystrophy protein (ALDP), which inhibits the oxidation of very long chain fatty acids (VLCFAs). Thus, these VLCFAs accumulate. In a cerebral for...

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Bibliografiske detaljer
Main Authors: Singh, Jaspreet, Khan, Mushfiquddin, Singh, Inderjit
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602866/
https://ncbi.nlm.nih.gov/pubmed/18723473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800321-JLR200
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