In Vivo Administration of a JAK3 Inhibitor to Chronically SIV Infected Rhesus Macaques Leads to NK Cell Depletion Associated with Transient Modest Increase in Viral Loads

Innate immune responses are reasoned to play an important role during both acute and chronic SIV infection and play a deterministic role during the acute stages on the rate of infection and disease progression. NK cells are an integral part of the innate immune system but their role in influencing t...

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Bibliographic Details
Main Authors: Takahashi, Yoshiaki, Mayne, Ann E., Khowawisetsut, Ladawan, Pattanapanyasat, Kovit, Little, Dawn, Villinger, Francois, Ansari, Aftab A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724739/
https://ncbi.nlm.nih.gov/pubmed/23923040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070992
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