A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions

Islet 1 (Isl1) is a transcription factor of the LIM-homeodomain (LIM-HD) protein family and is essential for many developmental processes. LIM-HD proteins all contain two protein-interacting LIM domains, a DNA-binding homeodomain (HD), and a C-terminal region. In Isl1, the C-terminal region also con...

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Autori principali: Gadd, Morgan S., Jacques, David A., Nisevic, Ivan, Craig, Vanessa J., Kwan, Ann H., Guss, J. Mitchell, Matthews, Jacqueline M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724647/
https://ncbi.nlm.nih.gov/pubmed/23750000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478586
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