Acquisition of Contextual Discrimination Involves the Appearance of a RAS-GRF1/p38 Mitogen-activated Protein (MAP) Kinase-mediated Signaling Pathway That Promotes Long Term Potentiation (LTP)

RAS-GRF1 is a guanine nucleotide exchange factor with the ability to activate RAS and RAC GTPases in response to elevated calcium levels. We previously showed that beginning at 1 month of age, RAS-GRF1 mediates NMDA-type glutamate receptor (NMDAR)-induction of long term depression in the CA1 region...

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Autores principales: Jin, Shan-Xue, Arai, Junko, Tian, Xuejun, Kumar-Singh, Rajendra, Feig, Larry A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724629/
https://ncbi.nlm.nih.gov/pubmed/23766509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471904
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