Diminished Acyl-CoA Synthetase Isoform 4 Activity in INS 832/13 Cells Reduces Cellular Epoxyeicosatrienoic Acid Levels and Results in Impaired Glucose-stimulated Insulin Secretion

Glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells is potentiated by fatty acids (FA). The initial step in the metabolism of intracellular FA is the conversion to acyl-CoA by long chain acyl-CoA synthetases (Acsls). Because the predominantly expressed Acsl isoforms in INS 832/13 ce...

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Detalhes bibliográficos
Main Authors: Klett, Eric L., Chen, Shufen, Edin, Matthew L., Li, Lei O., Ilkayeva, Olga, Zeldin, Darryl C., Newgard, Christopher B., Coleman, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724621/
https://ncbi.nlm.nih.gov/pubmed/23766516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481077
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