A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila

A large fraction of our genome consists of mobile genetic elements. Governing transposons in germ cells is critically important, and failure to do so compromises genome integrity, leading to sterility. In animals, the piRNA pathway is the key to transposon constraint, yet the precise molecular detai...

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Bibliographic Details
Main Authors: Muerdter, Felix, Guzzardo, Paloma M., Gillis, Jesse, Luo, Yicheng, Yu, Yang, Chen, Caifu, Fekete, Richard, Hannon, Gregory J.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724422/
https://ncbi.nlm.nih.gov/pubmed/23665228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.04.006
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