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Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands

We have used DNase I footprinting to examine the interaction of several triplex-binding ligands with antiparallel TG- and AG-containing triplexes. We find that although a 17mer TG-containing oligonucleotide on its own fails to produce a footprint at concentrations as high as 30 µM, this interaction...

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Bibliographic Details
Main Authors: Keppler, Melanie D., Neidle, Stephen, Fox, Keith R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37244/
https://ncbi.nlm.nih.gov/pubmed/11328877
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