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Two-stage case–control designs for rare genetic variants
The search for the association of rare genetic variants with common diseases is of high interest, yet challenging because of cost considerations. We present an efficient two-stage design that uses diseased cases to first screen for rare variants at stage-1. If too few cases are found to carry any va...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724230/ https://ncbi.nlm.nih.gov/pubmed/20352264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-010-0811-x |
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