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Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE(−/−) mice

OBJECTIVE: Interruption of the enterohepatic circulation of bile acids induces hepatic bile acid synthesis, increases hepatic cholesterol demand, and increases clearance of apoB-containing lipoproteins in plasma. Based on these effects, bile acid sequestrants have been used for many years to treat h...

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Autors principals: Lan, Tian, Haywood, Jamie, Dawson, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724224/
https://ncbi.nlm.nih.gov/pubmed/23880190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2013.05.017
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