Evidence for the involvement of G(i2) in activation of extracellular signal-regulated kinases in hepatocytes

BACKGROUND: Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F(2α) was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for G(i) proteins. RESULTS: Targeting the Gi(2α) expression by a specific ribozyme inhibited the...

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Bibliographic Details
Main Authors: Melien, Øyvind, Christoffersen, Thoralf, Sioud, Mouldy
Format: Artigo
Language:Inglês
Published: BioMed Central 2001
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37242/
https://ncbi.nlm.nih.gov/pubmed/11495629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-2-13
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