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Stressing HbF synthesis: role of translation?

In this issue of Blood, Hahn and Lowrey have identified phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) as a novel mechanism for the post-transcriptional induction of fetal hemoglobin (HbF). Furthermore, they demonstrate that this eIF2αP-mediated pathway works synergistically...

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Detalhes bibliográficos
Main Authors: Chen, Jane-Jane, Perrine, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724185/
https://ncbi.nlm.nih.gov/pubmed/23886772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506139
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