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Searching for Synergies: Matrix Algebraic Approaches for Efficient Pair Screening

Functionally interacting perturbations, such as synergistic drugs pairs or synthetic lethal gene pairs, are of key interest in both pharmacology and functional genomics. However, to find such pairs by traditional screening methods is both time consuming and costly. We present a novel computational-e...

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Autors principals: Gerlee, Philip, Schmidt, Linnéa, Monsefi, Naser, Kling, Teresia, Jörnsten, Rebecka, Nelander, Sven
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723843/
https://ncbi.nlm.nih.gov/pubmed/23935877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068598
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