Phenotype, Function, and Gene Expression Profiles of Programmed Death-1(hi) CD8 T Cells in Healthy Human Adults

T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that programmed death-1 (PD-1) regulates T cell dysfunction during chronic lymphocytic choriomeningitis virus infection in mice, and PD-1(hi) cells exhibit an intense exhausted gene signature. Th...

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Main Authors: Duraiswamy, Jaikumar, Ibegbu, Chris C., Masopust, David, Miller, Joseph D., Araki, Koichi, Doho, Gregory H., Tata, Pramila, Gupta, Satish, Zilliox, Michael J., Nakaya, Helder I., Pulendran, Bali, Haining, W. Nicholas, Freeman, Gordon J., Ahmed, Rafi
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723805/
https://ncbi.nlm.nih.gov/pubmed/21383243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001783
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